Caspase 14
Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene.[1][2][3]
The CASP14 gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.[3]
References
- ^ Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P (May 1999). "Identification of a new caspase homologue: caspase-14". Cell Death Differ 5 (10): 838–46. doi:10.1038/sj.cdd.4400444. PMID 10203698.
- ^ Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM (Dec 1998). "Caspase-14 is a novel developmentally regulated protease". J Biol Chem 273 (45): 29648–53. doi:10.1074/jbc.273.45.29648. PMID 9792675.
- ^ a b "Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23581.
See also
Further reading
- Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667.
- Ahmad M, Srinivasula SM, Hegde R, et al. (1998). "Identification and characterization of murine caspase-14, a new member of the caspase family.". Cancer Res. 58 (22): 5201–5. PMID 9823333.
- Eckhart L, Ban J, Fischer H, Tschachler E (2000). "Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation.". Biochem. Biophys. Res. Commun. 277 (3): 655–9. doi:10.1006/bbrc.2000.3698. PMID 11062009.
- Eckhart L, Declercq W, Ban J, et al. (2001). "Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation.". J. Invest. Dermatol. 115 (6): 1148–51. doi:10.1046/j.1523-1747.2000.00205.x. PMID 11121154.
- Lippens S, Kockx M, Knaapen M, et al. (2001). "Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.". Cell Death Differ. 7 (12): 1218–24. doi:10.1038/sj.cdd.4400785. PMID 11175259.
- Pistritto G, Jost M, Srinivasula SM, et al. (2003). "Expression and transcriptional regulation of caspase-14 in simple and complex epithelia.". Cell Death Differ. 9 (9): 995–1006. doi:10.1038/sj.cdd.4401061. PMID 12181750.
- Chien AJ, Presland RB, Kuechle MK (2002). "Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation.". Biochem. Biophys. Res. Commun. 296 (4): 911–7. doi:10.1016/S0006-291X(02)02015-6. PMID 12200134.
- Rendl M, Ban J, Mrass P, et al. (2003). "Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner.". J. Invest. Dermatol. 119 (5): 1150–5. doi:10.1046/j.1523-1747.2002.19532.x. PMID 12445205.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Lippens S, Kockx M, Denecker G, et al. (2004). "Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures.". Am. J. Pathol. 165 (3): 833–41. PMC 1618612. PMID 15331408. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1618612.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Walsh DS, Borke JL, Singh BB, et al. (2005). "Psoriasis is characterized by altered epidermal expression of caspase 14, a novel regulator of keratinocyte terminal differentiation and barrier formation.". J. Dermatol. Sci. 37 (1): 61–3. doi:10.1016/j.jdermsci.2004.10.003. PMID 15619438.
- Koenig U, Sommergruber W, Lippens S (2005). "Aberrant expression of caspase-14 in epithelial tumors.". Biochem. Biophys. Res. Commun. 335 (2): 309–13. doi:10.1016/j.bbrc.2005.07.072. PMID 16061209.
- Krajewska M, Kim H, Shin E, et al. (2006). "Tumor-associated alterations in caspase-14 expression in epithelial malignancies.". Clin. Cancer Res. 11 (15): 5462–71. doi:10.1158/1078-0432.CCR-04-2527. PMID 16061862.
- Kam DW, Charles AK, Dharmarajan AM (2005). "Caspase-14 expression in the human placenta.". Reprod. Biomed. Online 11 (2): 236–43. doi:10.1016/S1472-6483(10)60964-9. PMID 16168224.
- Park K, Kuechle MK, Choe Y, et al. (2006). "Expression and characterization of constitutively active human caspase-14.". Biochem. Biophys. Res. Commun. 347 (4): 941–8. doi:10.1016/j.bbrc.2006.06.156. PMID 16854378.
- White L, Dharmarajan A, Charles A (2007). "Caspase-14: a new player in cytotrophoblast differentiation.". Reprod. Biomed. Online 14 (3): 300–7. doi:10.1016/S1472-6483(10)60871-1. PMID 17359582.
- Hsu S, Qin H, Dickinson D, et al. (2007). "Expression of caspase-14 reduces tumorigenicity of skin cancer cells.". In Vivo 21 (2): 279–83. PMID 17436577.
External Links
- The MEROPS online database for peptidases and their inhibitors: C14.018
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